毒素菌和狂犬病-寄生虫,病毒,还是两者兼而有之?
Ragan Wilson1, Shannon Caseltine2, Edith Will1
1Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA.
Microorganisms
|January 25, 2025
概括
在提交狂犬病检测的动物小脑样本中的3.96%中检测到Toxoplasma gondii DNA. 这一发现突出了T. gondii作为模仿狂犬病的神经症状的潜在差异诊断.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 动物传播疾病 动物传播疾病
- 神经病理学神经病理学
背景情况:
- 淋巴状毒素是一种广泛传播的原生动物寄生虫,具有动物传染的潜力,已知会导致行为变化.
- 狂犬病病毒是一个重要的动物性病原体,在动物和人类中引起致命的神经系统疾病.
- 在T. gondii感染和狂犬病之间重叠的临床症状需要差异诊断.
研究的目的:
- 确定用于狂犬病检测的小脑组织中Toxoplasma gondii DNA的流行率.
- 评估T. gondii作为在狂犬病类似的临床症状的情况下进行差异诊断的潜力.
主要方法:
- 分析了2022年5月至2024年4月期间从22种动物中采集的903个小脑组织样本.
- 样品被提交给俄克拉荷马州动物诊断疾病实验室进行狂犬病检测.
- 使用分子方法进行了Toxoplasma gondii DNA检测.
主要成果:
- 在所有测试物种中,发现T. gondii DNA的总流行率为3.96%.
- 患病率因物种而异:猫的1.8%,狗的1.7%,臭的0.3%,牛的0.2%.
- 在狗中观察到T. gondii患病率的显著差异,分别是绝育 (7.94%) 和完整的雄性 (1.61%). 所有T. gondii阳性样本都是狂犬病负的.
结论:
- 毒淋巴菌在有神经症状的动物中普遍存在,经常出现可以被误认为是狂犬病的症状.
- 这项研究支持将T. gondii视为差异诊断,特别是当狂犬病检测结果为阴性时.
- 进一步调查T. gondii在各种动物物种神经疾病中的作用是有必要的.
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