益生菌补充剂通过调节肝脂发生和增加肉肠道微生物群多样性来缓解皮质诱导的脂肪肝疾病
Yuyan Feng1,2, Wenqing Mei2, Qu Chen2
1Institute of Animal Husbandry, Jiangsu Academy of Agricultural Sciences, Nanjing 210094, China.
Microorganisms
|January 25, 2025
概括
化后服用的益生菌通过调节脂质基因表达和改善肠道微生物群平衡,预防了 brojlers 中皮质激素诱导的脂肪肝疾病. 这项研究强调益生菌是预防脂肪肝疾病的潜在营养策略.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 新出现的证据将肠道微生物群与脂肪肝疾病 (FLD) 联系起来.
- 益生菌在改善动物和人类的FLD方面表现有前途.
- 益生菌在禽类中预防FLD的有效性仍在调查中.
研究的目的:
- 调查化后的益生菌补充是否可以预防肉中皮质 (CORT) 诱导的FLD.
- 为了确定益生菌效应与肝脏新生脂质生成和肠道微生物群组成的关联.
主要方法:
- 96只肉被分为控制 (CON) 和益生菌 (PB) 组.
- 在28天的年龄使用皮质 (CORT) 诱导脂肪肝.
- 分析包括体重,免疫器官体重,血和肝脏甘油三水平,肝脏脂肪生成基因表达 (SREBP1,ACC) 和通过16S rRNA测序的菌群组成.
主要成果:
- 益生菌的使用可以防止CORT诱导的体重减轻,但不能防止免疫器官的体重减轻.
- CORT增加了血和肝脏甘油三水平,脂肪和脂质生成基因表达;益生菌抵消了这些影响.
- CORT降低了肠道微生物的多样性,增加了蛋白质菌;益生菌增加了β多样性,丰富性和肠道的丰富性.
结论:
- 皮质激素诱导脂肪肝疾病,并改变肉的肠道微生物群.
- 化后的益生菌补充剂通过调节脂质基因表达和改善肠道微生物平衡来缓解 brojler 脂肪肝疾病.
- 益生菌代表了一种潜在的营养剂,可以预防的脂肪肝疾病.
相关概念视频
Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


