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在全身性硬化症中多模式查肺动脉高血压:当前的方法和未来的方向
Ioan Teodor Dragoi1,2, Ciprian Rezus3,4, Alexandra Maria Burlui1,2
1Department of Rheumatology and Physiotherapy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|January 25, 2025
概括
系统性硬化症 (SSc) 患有肺动脉高血压 (PAH) 风险的患者可以从非侵入性查中获益. 心声学和生物标志物有助于识别PAH,减少了对侵袭性右心导管导管的需要.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
背景情况:
- 系统性硬化症 (Systemic Sclerosis,SSc) 是一种免疫-炎症性疾病,会导致影响器官的纤维化.
- 肺动脉高血压 (PAH) 是SSc的严重并发症,增加死亡率.
- 右心脏导管 (RHC) 是PAH诊断的黄金标准,但具有侵入性.
研究的目的:
- 审查SSc-PAH的非侵入性查方法.
- 要突出早期检测PAH在SSc患者的重要性.
- 讨论心声回声,生物标志物和肺功能测试的作用.
主要方法:
- 关于SSc-PAH查的当前文献的综述.
- 分析回声心脏学在评估右心脏结构和功能的实用性.
- 血清生物标志物的评估 (NT-proBNP,尿酸,新型标志物) 和肺功能测试.
主要成果:
- 心声图是SSc-PAH查的一个关键的非侵入性工具.
- 血清生物标志物,包括新的生物标志物,有助于风险识别和预后.
- 肺功能测试有助于为RHC选择患者.
结论:
- 由于RHC的侵入性,非侵入性查对SSc-PAH至关重要.
- 使用心声回声,生物标志物和PFTs的多模式方法改善了SSc-PAH检测.
- 早期识别有助于及时干预,并改善SSc患者的PAH的治疗结果.
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