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在高级帕金森病患者视角下对输液疗法的满意度和偏好
Julia Węgrzynek-Gallina1, Tomasz Chmiela1, Michał Borończyk2
1Department of Neurology, Faculty of Medical Sciences in Katowice, University Clinical Centre Prof K. Gibinski, Medical University of Silesia, 14 Medykow St. 40-752 Katowice, Poland.
Medicina (Kaunas, Lithuania)
|January 25, 2025
概括
患有晚期帕金森病 (PD) 的患者对设备辅助疗法 (DAT) 的满意度不同. 对手术的恐惧和安全问题显著影响了人们对利沃多巴-卡比多巴肠凝 (LCIG) 和持续皮下阿波莫芬输液 (CSAI) 的偏好.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期帕金森病 (PD) 需要设备辅助疗法 (DATs),如勒沃多巴-卡比多巴肠凝 (LCIG) 和连续皮下阿波莫尔芬输液 (CSAI).
- 晚期PD的患病率越来越高,推动了对有效DAT的需求,突出了了解患者经验和偏好的必要性.
研究的目的:
- 在晚期帕金森病中评估患者对LCIG和持续皮下阿波莫尔芬输液 (CSAI) 的满意度.
- 确定影响患者在LCIG和CSAI疗法之间偏好的关键因素.
主要方法:
- 在一所大学医院接受DAT的50名晚期帕金森病患者进行了电话调查.
- 用帕金森病问卷 (PDQ-8) 和家庭护理人员压力表 (BSFC-s) 来评估患者的经验.
- 医疗记录提供了有关疾病和治疗特征的数据,以及排除治疗的原因.
主要成果:
- 与CSAI患者相比,LCIG患者报告了较高的PDQ-8得分 (20对13) 和BSFC-s得分 (19对9),表明疾病影响和护理人员压力更大.
- 对手术的恐惧 (75%对36.8%) 和对DAT安全性的担忧 (83.3%对47.4%) 是影响患者偏好的重要因素.
- 患者的平均年龄相似 (CSAI为70.6 ± 4.7,LCIG为71.2 ± 7.2),疾病持续时间分别为15年 (IQR: 12-19) 和18年 (IQR: 13-19).
结论:
- 对于高级帕金森病的管理,LCIG和CSAI都提供了明显的好处和缺点.
- 患者在LCIG和CSAI之间做出决定,主要是因为他们对手术程序的担忧以及设备辅助疗法的安全性.
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