用免疫检查点抑制剂治疗患者的内分泌不良事件:全面分析
Meriç Dökmetaş1, Harun Muğlu1, Erkan Özcan2
1Department of Medical Oncology, Faculty of Medicine, Medipol University, Istanbul 34810, Turkey.
Medicina (Kaunas, Lithuania)
|January 25, 2025
概括
免疫检查点抑制剂 (ICI) 可以导致内分泌的副作用,如甲状腺功能低下症. 这些免疫相关不良事件 (irAEs) 的早期管理至关重要,可能与更好的癌症治疗结果相关.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
- ICI治疗与免疫相关的不良事件 (irAEs) 有关,包括内分泌功能障碍.
- 了解ICI相关的内分泌毒性对于患者护理至关重要.
研究的目的:
- 确定接受ICI的癌症患者内分泌IRAE的发生率,时间和管理.
- 评估这些内分泌副作用对治疗结果的影响.
- 探索iRAE与临床益处之间的关系.
主要方法:
- 对139名接受ICI治疗的癌症患者 (2016-2022) 的回顾性分析.
- 收集关于内分泌IRAE的数据:甲状腺功能低下症,甲状腺功能过强症,低体质炎,糖尿病.
- 评估irAE发作,管理策略,以及与客观反应率 (ORR) 和临床益处率 (CBR) 的关联.
主要成果:
- 甲状腺功能低下是最常见的内分泌IRAE (65.5%),其次是低甲状腺炎 (8.6%).
- 内分泌IRA通常发生在ICI启动后的6个月内.
- 与没有内分泌irAEs的患者相比,具有内分泌irAEs的患者显示出更高的ORR和CBR.
结论:
- 内分泌功能障碍是与ICI治疗相关的显著毒性.
- 及时诊断和管理内分泌IRAE对于患者的健康至关重要.
- ICI诱导的内分泌IRAE可能与改善的抗瘤疗效有关,这需要进一步研究.
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