在COVID-19后患者的心脏血液动力学,组织氧化和功能能力
Elizane Poquiviqui do Nascimento1,2, Larissa Fernanda Estevam do Nascimento1,2, Lhara de Freitas Castro1,2
1Laboratório de Inovação Tecnológica em Reabilitação, Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte (UFRN), Campus Universitário Central, Natal 59078970, RN, Brazil.
与对照组相比,COVID-19后患者表现出功能能力下降和心脏血液动力学变化,包括中风体积和心脏指数下降. 肌肉氧化率保持相似,表明病毒的特定心血管影响.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 运动生理学 运动生理学
背景情况:
- 长期的COVID可能会影响心血管功能和运动能力.
- 了解COVID-19后的生理变化对于康复至关重要.
研究的目的:
- 为了比较后COVID-19患者和对照组之间的功能能力.
- 在COVID-19后患者的功能测试期间分析心脏血液动力学和肌肉氧化.
主要方法:
- 横截面研究比较36名COVID-19后患者与11名对照组 (所有人≥18岁).
- 使用一分钟的坐立测试 (1-STS) 和六分钟的步行测试 (6MWT) 评估功能能力.
- 在1-STS期间通过阻抗测量心脏血液动力学;在测试期间和之后监测组织氧化.
主要成果:
- 后COVID-19组的6MWT距离降低了20% (p=0.0001) 和1-STS重复减少了28% (p=0.01).
- 在1-STS期间,COVID-19后组的显著血液动力学变化:中风体积指数减少 (18%),心脏指数减少 (21%),射出分数减少 (29%);全身血管抵抗增加 (25%).
- 在测试期间,群体之间肌肉氧化没有显著差异.
结论:
- 后COVID-19个人表现出功能能力下降.
- 显而易见的是心脏血液动力学的改变,特别是心脏输出减少和血管抵抗增加.
- 运动期间的肌肉氧化模式被保留,这表明有针对性的心血管功能障碍.
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