药物诱导的肌:一个系统的审查
Jamir Pitton Rissardo1, Ana Letícia Fornari Caprara1, Nidhi Bhal2
1Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA.
Medicina (Kaunas, Lithuania)
|January 25, 2025
概括
药物诱导性肌细胞瘤 (DIM) 与许多药物有关,包括麻醉剂,抗生素和抗抑郁药. 管理可能包括停止侵权药物或调整剂量以扭转这种异常的非自愿运动.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肌肉是一种与各种药物和全身疾病相关的异常非自愿运动.
- 发现新的药物关联需要对导致药物诱导肌瘤 (DIM) 的药物进行全面审查.
研究的目的:
- 系统地审查和评估与药物诱导肌瘤 (DIM) 相关的药物.
主要方法:
- 从1955年到2024年,使用搜索术语"myoclonus"对PubMed数据库进行了系统审查.
- 药物被分为类别和子类别,证据水平被分配到子类.
- 两个独立的审稿人评估了获取的文章.
主要成果:
- 从12097个结果中确定了1115例DIM.
- 具有A级证据的药物包括静脉注射麻醉剂 (埃托米达),头素 (ceftazidime,cefepime),基诺 (ciprofloxacin),SSRI (citalopram,escitalopram,paroxetine,sertraline),TCAs (amitriptyline) 等.
- 埃托米达是最频繁报告的致病剂;神经递质如血清素,多巴胺,GABA和谷氨酸都与此有关.
结论:
- 药物诱导性肌瘤 (DIM) 通常通过药物停用,剂量调整或治疗异常性肌瘤可逆.
- 根据临床表现和病理生理学,DIM可以分为三种类型:血清综合征,非血清综合征和未知.
- 这种分类有助于理解和管理药物诱导的肌细胞瘤.
相关概念视频
Classification of Skeletal Muscle Relaxants
2.4K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
2.4K
Skeletal Muscle Relaxants: Adverse Effects
332
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
332
Spasmolytic Agents: Chemical Classification
853
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
853
Myasthenia Gravis: Overview and Treatment
1.1K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.1K
Skeletal Muscle Relaxants: Therapeutic Uses
462
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
462
Myasthenia Gravis: Diagnostic Tests
604
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
604


