系统性炎症和临床病理特征对恶性多层层层瘤生存的影响:多中心分析
Nadiye Sever1, Sedat Yıldırım2, Ali Fuat Gurbuz3
1Medical Oncology, Department of Internal Medicine, Marmara University Faculty of Medicine, İstanbul 34854, Turkey.
Medicina (Kaunas, Lithuania)
|January 25, 2025
概括
反应性C蛋白/白蛋白比率 (CAR) 是恶性多叶膜间皮瘤 (MPM) 患者生存的关键预测指标. 较低的CAR值与明显更长的整体和无进展生存时间相关,突出显示了其预后的重要性.
科学领域:
- 在瘤学瘤学.
- 胸部医学 胸部医学
- 生物标志物研究 生物标志物研究
背景情况:
- 恶性多层层层瘤 (MPM) 是一种具有有限预后因素的侵袭性癌症.
- 准确的风险分层对于量身定制MPM治疗至关重要.
- 系统性炎症和营养状况可能会影响MPM的预后.
研究的目的:
- 研究MPM中临床病理因素和系统性炎症标志物的预后价值.
- 评估C反应蛋白/白蛋白比率 (CAR) 和中性粒细胞与淋巴细胞比率 (NLR) 对生存结果的影响.
主要方法:
- 对217名MPM患者进行了回顾性多中心研究.
- 收集的数据:人口统计,组织学,阶段,治疗,NLR和CAR.
- 使用卡普兰-梅尔和考克斯回归的生存分析.
主要成果:
- C-反应蛋白/白蛋白比率 (CAR) 是整体存活 (OS) 和无进展存活 (PFS) 的独立预后因素.
- 患有CAR<0.98的患者表现出显著更长的OS (87.0个月) 和PFS (17.61个月).
- 表皮质组织学和早期疾病与改善的生存率有关.
结论:
- CAR是MPM中强大的独立预后标志物,反映了炎症和营养状况.
- 表皮质组织学和早期疾病阶段显著改善了患者的存活率.
- 早期发现和评估CAR对于优化MPM患者的治疗结果至关重要.
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