内皮功能障碍和静血系统激活与轮班工作者,社会时差和女性护士的时型有关
Gleb Saharov1,2, Barbara Salti1, Maram Bareya1
1Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa 3109601, Israel.
International journal of molecular sciences
|January 25, 2025
概括
轮班工作,社交时差和晚期的时刻型会损害内皮功能,增加护士的早晨血栓形成风险. 维持每日生物节奏对于心血管健康至关重要.
科学领域:
- 心血管科学 心血管科学
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 轮班工作,社会时差 (SJL) 或时型的循环失调可能会增加心血管疾病的风险.
- 内皮功能障碍和高凝血能力是心血管病理的关键预测因素.
研究的目的:
- 调查轮班工作,SJL和时间型对护士女性内皮功能和凝血参数的影响.
- 评估这些标记物的日间变化.
主要方法:
- 100名女护士接受了内皮功能测试 (EndoPAT) 和血液采样以检测凝血标志物.
- 每天测量两次 (早上和晚上).
- 分析了轮班工人,白天工人,SJL和时间型.
主要成果:
- 与白天工人相比,轮班工人表现出较低的内皮功能和纤维素素,与较高的等离子素激活剂抑制剂-1 (PAI-1) 和肝激酶水平相比.
- 高SJL与较差的内皮功能和升高的PAI-1,肝酶和D-Dimer相关.
- 晚期时代型表现出比早期时代型更高的PAI-1和肝酶活性.
- 对于PAI-1,von-Willebrand因子 (vWF),肝酶和肝硫酸盐,观察到白天变化,其中早上峰值.
结论:
- 轮班工作,高SJL和晚期时刻型与内皮功能障碍和血栓形成风险增加有关.
- 血栓形成的风险在早上升高,无论昼夜失调的原因是什么.
- 坚持每日生物节奏至关重要;肝激酶抑制剂可能会减轻失调个体的风险.
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