肝硬化中的微生物群的系统审查:向更病原性倾向的变化
Elias Xirouchakis1,2, Alexandros Pelekanos1, Spyridon Xirouchakis2,3
1Gastroenterology-Liver-Endoscopy Unit, 2nd Department of Internal Medicine, General Hospital of Athens "Hippocration", National and Kapodistrian University of Athens, 115 27 Athens, Greece.
International journal of molecular sciences
|January 25, 2025
概括
肠道微生物群的改变与肝硬化及其并发症有关. 本综述强调了肝硬化患者肝脏脑病和肝细胞癌相关的多样性减少和细菌特异性变化.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 人体肠道微生物组在调节免疫反应和新陈代谢方面发挥着至关重要的作用.
- 在肝硬化及其相关并发症中观察到肠道微生物群组成和多样性的变化.
- 了解这些微生物变化对于控制肝病进展至关重要.
研究的目的:
- 系统地审查当前关于肠道微生物群在肝硬化中的改变的知识.
- 基于肝硬化病因学,探索微生物群特征的潜在差异.
- 阐明肠道失生症在肝硬化并发症发展中的作用.
主要方法:
- 进行了系统的文献搜索,直到2024年7月.
- 包括的研究包括随机对照试验,观察性研究和成年肝硬化患者的队列研究.
- 从73个选定的出版物中提取和分析数据.
主要成果:
- 在78%的研究中,肠道微生物群的α多样性下降,而β多样性在健康和肝硬化群之间有显著差异 (90%).
- 蛋白质细菌显著增加 (74%),而Firmicutes和Bacteroidetes在肝硬化患者中减少.
- 肝脏脑病变中存在大量的病原生物,如Enterococcus和Streptococcus,而在肝细胞癌中,α多样性显示出异质性.
结论:
- 肠道微生物群失生症与肝硬化有显著的关联.
- 微生物群的变化在肝硬化并发症的发病过程中发挥着作用,包括肝脑病变和肝细胞癌.
- 需要进一步的研究来探索有针对性的治疗策略,以调节肝病中的肠道微生物群.
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