非传统动脉样硬化疾病中的残留传统风险
Federico Biscetti1,2, Giorgia Polito1, Maria Margherita Rando1
1Cardiovascular Internal Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
International journal of molecular sciences
|January 25, 2025
概括
患有慢性炎症和免疫疾病的个人面临更高的动脉样硬化事件的风险. 需要新的工具来有效评估和管理这种"非传统"心血管疾病风险.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 慢性炎症和免疫疾病显著增加动脉样硬化事件和早发性心血管疾病 (CVD) 的风险.
- 现有关于与这些疾病相关的"非传统"心血管风险因素的研究仍然没有解决关键方面,包括潜在的机制和有效的管理策略.
- 当前的心血管风险评估工具往往未能纳入这些非传统的风险因素,导致潜在的低估心血管疾病风险.
研究的目的:
- 审查和评估关于关键"非传统"心血管风险增强条件的证据.
- 评估目前在这些患者群体中评估和管理心血管风险的战略.
- 发现知识上的差距,并倡导开发改进的风险评估工具.
主要方法:
- 一个全面的文献综述412篇文章,包括原创研究,评论和元分析.
- 分析的重点是将非传统疾病与心血管风险联系在一起的机制.
- 检查目前对心血管风险评估和管理的方法.
主要成果:
- 证据证实了炎症/免疫疾病与动脉样硬化风险增加之间的联系.
- 一个重大挑战是量化个体风险因素和疾病特异因素对整体心脏病风险的贡献.
- 目前的指导方针缺乏针对非传统心血管风险因素的治疗方法的具体建议,并且没有包含这些因素的经过验证的风险评分.
结论:
- 迫切需要提高意识,改善心血管风险评估和管理的策略,在患有"非传统心血管风险增强条件"的患者中.
- 准确的CVD风险预测需要全面了解所有促成因素,包括疾病特异性因素.
- 未来的研究应该优先发展创新的,特定于疾病的心血管风险评估工具,整合非传统风险因素.
相关概念视频
01:17Ischemic Heart Disease: Overview
1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
115
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
115
01:26Traditional Level Of Health Care System
2.6K
The levels of care describe the services provided in the healthcare system. Accordingly, there are six levels of the traditional healthcare system in the US: preventive, primary, secondary, tertiary, restorative, and continuing healthcare. A nurse must understand how the healthcare industry organizes and provides services within these levels of care.
The preventive healthcare service includes tests for screening. Preventive health care services include identifying and reducing disease risk...
The preventive healthcare service includes tests for screening. Preventive health care services include identifying and reducing disease risk...
2.6K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
375
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
375
01:20Vascular Resistance
3.3K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
3.3K
01:31Adrenergic Antagonists: ɑ and β-Receptor Blockers
405
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
405