甲状腺功能低下症改变了周期性大鼠的子宫基斯佩普丁系统和活动调节器
Thayná Queiroz Menezes da Silva1, Erikles Macêdo Barbosa1, Luciano Cardoso Santos1
1Electron Microscopy Center, Department of Biological Sciences, State University of Santa Cruz, Ilheus 45662-900, Brazil.
International journal of molecular sciences
|January 25, 2025
概括
甲状腺功能低下症通过降低子宫kisspeptin (Kp) 和其受体 (Kiss1r) 表达来破坏女性的生育能力. 这会影响子宫受体媒介和激素信号传递,导致不孕.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 分子生物学分子生物学
- 动物模型 动物模型
背景情况:
- 甲状腺功能低下症与卵巢功能障碍和不孕症有关.
- 基斯平素 (Kp) 和它的受体 (Kiss1r) 在生殖中发挥作用,包括子宫受体性.
- 甲状腺功能低下症对子宫Kp/Kiss1r表达和相关因素的影响尚不清楚.
研究的目的:
- 研究甲状腺功能低下症对雌性大鼠子宫Kp和Kiss1r表达的影响.
- 在整个雌性周期内分析子宫活动调节器和受体调节器的相关变化.
主要方法:
- 在雌性大鼠中使用甲 (PTU) 诱导的甲状腺功能低下症.
- 评估了血激素 (LH,E2,P4),雌激素周期性,子宫组织形态测量以及基因/蛋白质表达 (Kiss1,Kiss1r,ERα,PR,TRα).
- 评估的增殖活性 (CDC-47) 和子宫受容性媒介 (SMO,WNT4,BMP2,HAND2,MUC1,LIF). 这两种类型的药物具有非常强的作用.
主要成果:
- 甲状腺功能低下症改变了雌激素周期性,延长了雌激素周期,并影响了激素特征 (增加P4,减少LH/E2).
- 观察到子宫Kp免疫染和Kiss1rmRNA水平的降低.
- 观察到子宫内膜腺减少,子宫增殖,ERα表达和子宫受容性媒介 (LIF,BMP2,WNT4,HAND2).
结论:
- 甲状腺功能低下会损害大鼠的子宫kisspeptin/Kiss1r系统.
- 这种损伤与被破坏的子宫雌激素/孕信号传递有关.
- 降低子宫受体性媒介体的表达有助于在甲状腺功能低下状态下导致不孕.
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