提高原蛋白的可溶性和溶解:固体分散方法
Natalia Rosiak1, Ewa Tykarska2, Andrzej Miklaszewski3
1Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.
International journal of molecular sciences
|January 25, 2025
概括
这项研究使用Pluronic F-127 (PLU127) 固体分散增强了阿皮基因 (APG) 溶解度. APG-PLU127显示出更好的溶解性和抗氧化活性,突出了其在口服药物输送方面的潜力.
科学领域:
- 药理学和制药学 药理学和制药学
- 材料科学 材料科学 材料科学
背景情况:
- 原蛋白 (APG) 是一种黄类化合物,具有治疗潜力,但水溶性差限制了生物可用性.
- 固体分散为克服药物溶解性差并提高治疗效率提供了一种策略.
研究的目的:
- 通过使用固体分散来提高阿皮基宁 (APG) 的可溶性和生物可用性.
- 评估不同聚合物助剂的性能,重点是Pluronic F-127 (PLU127),用于APG输送.
主要方法:
- 通过使用各种聚合物进行球磨,包括Pluronic F-127 (PLU127) 等,制备了APG的固体分散物.
- 评估了溶解度,溶解率,分子相互作用 (DSC,FT-IR),稳定性和抗氧化活性 (ABTS测定).
主要成果:
- APG-PLU127分散在各种pH值 (1.2,5.5,6.8) 中显著提高溶解度.
- 通过DSC和FT-IR确认的分子相互作用有助于提高溶解度和溶解度.
- 储存一年后,APG-PLU127保持了显著的抗氧化活性,尽管溶解度发生了轻微的变化.
结论:
- 普鲁罗尼克F-127 (PLU127) 是一种优越的载体,可增强阿皮基因 (APG) 溶解度,释放和抗氧化活性.
- APG-PLU127固体分散显示出开发有效的口服剂型的前景.
- 配方策略有效地解决了apigenin的生物可用性挑战.
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