描述2型糖尿病亚型的循环微RNA特征
Fatima Sulaiman1, Costerwell Khyriem1, Stafny Dsouza1
1College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.
International journal of molecular sciences
|January 25, 2025
概括
2型糖尿病 (T2D) 亚型表现出独特的循环微RNA (miRNA) 表达特征. 这种表观遗传区别突出了miRNAs作为理解T2D异质性和病理生理学的潜在生物标志物.
科学领域:
- 内分泌学和新陈代谢学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 2型糖尿病 (T2D) 是一种复杂,异质的疾病,受遗传和环境因素的影响.
- 新出现的证据表明,T2D亚型之间存在不同的基因表达特征.
- 了解这些表观遗传差异对于个性化医学至关重要.
研究的目的:
- 为了确定5个先前定义的T2D临床亚型的特定微RNA (miRNA) 表达特征.
- 调查T2D异质性的表观遗传基础.
- 探索循环miRNAs作为T2D病理生理学的生物标志物的潜力.
主要方法:
- 来自45名T2D患者的循环miRNA的单端小RNA测序,分布在五个亚型 (SIRD,SIDD,MARD,MOD,MEOD) 和7个健康对照组中.
- 生物信息分析用于识别已知的和新的循环miRNAs.
- 差异表达分析用于比较T2D亚型和对照之间的miRNA配置文件.
主要成果:
- 鉴定了430种已知和13种新发的循环miRNAs.
- 与对照组相比,在T2D亚型中,有71个miRNA被上调和37个被下调.
- 每个T2D亚型都表现出独特的,失调的miRNA配置文件,特定的miRNA与SIRD,MARD,MOD和MEOD独特相关.
- 对于SIRD,SIDD,MARD和MEOD观察到上调和下调的miRNA的明显模式.
结论:
- 证实了2型糖尿病的显著临床和表观遗传异质性.
- 证明循环miRNA表达形状对于每个T2D亚型是不同的.
- 突出了miRNAs作为诊断和预后生物标志物的潜在实用性,用于区分T2D病理生理学.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500
Pathophysiology of Diabetes
854
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
854


