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同类氨酸代谢物,内皮功能障碍和心血管疾病

Hieronim Jakubowski^1,2, Łukasz Witucki²

¹Department of Microbiology, Biochemistry and Molecular Genetics, International Center for Public Health, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.

International journal of molecular sciences

|January 25, 2025

概括

高水平的同类氨酸 (Hcy) 和其代谢物,如Hcy-thiolactone,通过促进炎症和改变基因表达,驱动内皮功能障碍和心血管疾病 (CVD). 向这些代谢物可能为动脉样硬化和中风提供新的治疗策略.

科学领域:

心血管科学心血管科学
生物化学生物化学
分子生物学分子生物学

背景情况:

动脉样硬化和心血管疾病 (CVD) 是全球主要的死亡原因,由炎症和内皮功能障碍驱动.
超homocysteinemia (HHcy),以高水平的同类氨酸 (Hcy) 为特征,是心血管疾病的重要危险因素.
内皮功能障碍是动脉样硬化的最初阶段,其结果是破坏血管平衡的因素,包括HHcy.

研究的目的:

阐明Hcy代谢物对内皮功能障碍,心血管疾病和中风的作用机制.
探索表观遗传修饰在Hcy诱导的血管病理中的作用.
为了确定与Hcy相关的血管并发症的潜在治疗点.

主要方法:

对同类氨酸代谢和心血管疾病的流行病学,生物化学和临床研究的审查.
通过Hcy代谢物 (例如N-homocysteinylated蛋白质) 对蛋白质的生物化学修饰的分析.
研究表观遗传机制,包括microRNA和基因素修饰,涉及Hcy诱导的血管损伤.

主要成果:

增加的Hcy,Hcy-thiolactone和N-Hcy蛋白质会促进内皮功能障碍,炎症和动脉动脉变化.
Hcy代谢物诱导表观遗传变化,包括mTOR信号上调和通过microRNA和基因组修饰抑制自.
囊氨酸和Hcy-thiolactone通过对血液凝固的影响与心肌梗塞和缺血性中风有关.

结论:

Hcy代谢物是内皮功能障碍和动脉样硬化的关键驱动因素,有助于心血管疾病和中风.
表观遗传失调在Hcy诱导的血管疾病的发病过程中起着至关重要的作用.
准Hcy代谢及其下游影响为预防和治疗心血管疾病提供了一个有希望的途径.

关键词:

这是一种S-adenosylhomocysteine.抗炎蛋白质是一种抗炎蛋白质.抗氧化蛋白质是一种抗氧化蛋白质.心血管疾病心血管疾病囊氨酸 (cystathionine) 是一种氨酸.内皮质功能障碍在内皮质功能障碍基因组脱甲基酶PHF8 基因组脱甲基酶 PHF8 同型半氨酸 thiolactone 的使用情况.甲基化组织素 H4K20me1 这是一个微型RNA.蛋白质组学是什么意思一次性中风中风中风中风中风

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