在Pomacea canaliculate中的毒理学影响:积累,氧化应激,微生物群落和转录组分析
Mingxin Qiu1, Xiaoyang Bi1, Yuanyang Liu1
1Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China.
International journal of molecular sciences
|January 25, 2025
概括
污染会通过在器官中积累,减少抗氧化酶和改变肠道微生物来伤害淡水牛. 这些有毒效应即使在去除后也会持续存在,影响细胞过程.
科学领域:
- 环境毒理学环境毒理学
- 水生无脊椎动物生物学
- 生态毒理学 生态毒理学
背景情况:
- (Cd) 污染是一个严重的环境问题.
- 关于淡水无脊椎动物中Cd毒性的数据有限.
- 果牛 (Pomacea canaliculata) 是重要的淡水无脊椎动物.
研究的目的:
- 研究Pomacea canaliculata中的Cd积累和毒理学影响.
- 分析氧化应激,肠道微生物变化和转录基因变化.
- 确定Cd毒性在消除期后的持续性.
主要方法:
- 暴露P. canaliculata在10μg/L的Cd溶液中16天.
- 随后的16天消除期来评估Cd的净化.
- 测量组织中的Cd度,抗氧化酶活性 (SOD,CAT,GST) 和肠道微生物多样性.
- 转录组分析以确定差异表达基因 (DEG).
主要成果:
- 肝脏显示Cd积累最高,其次是脏和肠胃.
- 在排泄过程中,Cd度下降,在头脚和贝中显著下降.
- Cd压力降低了SOD,CAT和GST活动,在净化后的影响持久.
- 肠道微生物多样性下降,DEG与溶酶体功能,蛋白质加工和代谢途径有关.
结论:
- 显著影响P. canaliculata,影响组织积累,氧化应激和肠道微生物群.
- 毒理效应,特别是对酶活性的影响,在Cd消除后仍然存在.
- 压力扰乱细胞运输和代谢过程,突出其对水生生物的广泛影响.
相关概念视频
01:36Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
00:57The Periodic Table and Organismal Elements
175.1K
Overview
175.1K