血管细胞粘附分子1和E-选择素作为牛皮的潜在心血管风险生物标志物
Natalia Joanna Machoń1, Natalia Zdanowska2, Paulina Klimek-Trojan2
1School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland.
International journal of molecular sciences
|January 25, 2025
概括
血管细胞粘附分子-1 (VCAM-1) 和E-selectin是牛皮炎炎症和心血管风险的关键生物标志物. 监测它们的水平可以表明治疗的有效性和疾病的进展.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 心血管医学 心血管医学
- 生物标志物发现发现
背景情况:
- 牛皮与心血管风险增加有关,包括内皮细胞激活.
- 在炎症过程中,VCAM-1和E-selectin是关键的粘附分子.
研究的目的:
- 审查VCAM-1和E-selectin作为牛皮的生物标志物的作用.
- 探索它们与心血管风险和治疗反应的联系.
主要方法:
- 对VCAM-1,E-selectin,牛皮和心血管疾病的研究进行文献综述.
- 分析影响生物标志物水平和治疗效果的因素.
主要成果:
- VCAM-1和E-选择素水平与牛皮的严重程度和内皮细胞激活相关.
- 诸如TNF-α抑制剂和UVB疗法等疗法会影响这些标记物.
- 年龄,代谢综合征和吸烟会影响生物标志物水平.
结论:
- 在牛皮中,VCAM-1和E-selectin显示出作为炎症,疾病严重程度和心血管风险的生物标志物的潜力.
- 了解它们的作用有助于管理牛皮和相关疾病.
相关概念视频
Selectins
3.2K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
53
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
53
Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25


