低急性PM2.5暴露会通过炎症和氧化应激诱导肝脏胰岛素抵抗
Yao Lu1, Wenke Qiu2, Ruiwei Liao1
1School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, No. 232, East Waihuan Road, Guangzhou Higher Education Mega Centre, Panyu District, Guangzhou 510006, China.
International journal of molecular sciences
|January 25, 2025
概括
短时间暴露在微粒物质2.5 (PM2.5) 中会通过诱导氧化应激,炎症和抑制PI3K-AKT通路引起胰岛素耐药性 (IR),从而导致肝脏功能障碍.
科学领域:
- 环境健康 环境健康
- 代谢障碍 代谢障碍 代谢障碍
- 毒理学 毒理学 毒理学
背景情况:
- 流行病学研究将细颗粒物2.5 (PM2.5) 暴露与II型糖尿病联系起来.
- 确切的机制,PM2.5诱导肝功能障碍和胰岛素抵抗 (IR),特别是短期暴露,并没有完全理解.
研究的目的:
- 研究PM2.5暴露如何影响胰岛素敏感性和葡萄糖代谢.
- 阐明潜在的分子机制,包括氧化应激,炎症和信号通路变化,将PM2.5暴露与IR联系起来.
主要方法:
- 使用HepG2细胞和BALB/c小鼠模型进行PM2.5暴露研究.
- 使用商业套件和腹腔内葡萄糖耐受性测试评估葡萄糖代谢.
- 通过RT-qPCR和光染色进行量化氧化应激标志物 (ROS,MDA,SOD,SIRT1),炎症性细胞因子 (IL-6,TNF-α).
- 使用西方斑点分析检查PI3K-AKT通路的激活.
主要成果:
- 低急性PM2.5暴露在HepG2细胞和小鼠中诱导了胰岛素抵抗,由改变的葡萄糖和胰岛素水平和受损的葡萄糖耐受性证明.
- 暴露于PM2.5显著增加了氧化应激标志物和上调的炎症细胞因子IL-6和TNF-α.
- 在PM2.5暴露时,PI3K-AKT信号通路受到抑制,PI3K/AKT酸化降低.
- 组织病理学检查显示,在小鼠中,只有轻度肝损伤.
结论:
- 低急性PM2.5暴露会通过一连串涉及氧化应激,炎症和PI3K-AKT通路抑制的过程触发胰岛素抵抗.
- 这些发现凸显了PM2.5等环境污染物在代谢功能障碍中的关键作用,并为糖尿病的发展提供了机理性的见解.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
69
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
69
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:27Acute Pancreatitis I: Introduction
332
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
332
01:20Pathophysiology of Diabetes
854
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
854