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通过通过超临界流体技术与三进行无形化,提高黄素的可溶性和生物活性

Ewa Garbiec¹, Natalia Rosiak¹, Szymon Sip¹

¹Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3 Str., 60-806 Poznan, Poland.

International journal of molecular sciences

|January 25, 2025

概括

这项研究增强了黄素的功效.

科学领域:

制药科学制药科学
材料科学材料科学材料科学

背景情况:

黄素表现出抗氧化和神经保护性质,但其水溶性较差.
像无形固体分散和共同无形系统这样的无形化技术被用来提高黄素的可溶性.
结合无形化策略提供了一种新的方法来提高黄素的生物可用性.

研究的目的:

开发和描述黄素的新型无形系统,使用托作为前者.
评估无形化和共同形成对黄素溶解性,溶解性,透性和生物活性的影响.
研究超临界流体技术在制造先进的黄素配方方面的潜力.

主要方法:

使用超临界流体技术制备无形固体分散和三元共形系统.
使用X射线粉末衍射 (XRPD),富里埃变换红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 进行无形系统的表征.
评估黄素的可溶性,溶解速率和体外透性 (PAMPA试验).
对抗氧化剂活性和酶抑制 (乙基胆酶) 的评估.

主要成果:

黄素系统的无形性质通过XRPD证实;FTIR表明了分子相互作用.
由于无形化,SEM显示了粒子形态的显著变化.
用托的三级系统增加了库尔库的溶解度超过300倍.
无形黄素表现出更高的溶解率;托系统显示了 >3倍的提高透性.
增强的溶解性导致抗氧化活性增加了6倍以上,基胆酶抑制提高了25倍.

结论:

超临界流体技术有效地产生了无形的黄素系统,包括用托制成的三元系统.
作为辅助剂的托芬显著增强了黄素的溶解性,透性和生物活性.
这些发现突出了通过先进的配方方法改善黄素治疗潜力的有希望的策略.

关键词:

没有形状的无形.库尔库明是一种黄素.超临界流体技术的超临界流体技术托芬三聚氨酸是什么

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