对CMR确定的细胞外体积指标进行比较评估,以预测不良结果
Katharina Mascherbauer1, Christina Kronberger1, Carolina Donà1
1Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Journal of clinical medicine
|January 25, 2025
概括
通过心血管磁共振成像测量的细胞外体积 (ECV) 和索引ECV (iECV) 均预测了诸如心力衰竭住院和死亡等不良结果. 然而,更简单的ECV测量是足够的,因为iECV没有增加显著的预后价值.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 通过心血管磁共振 (CMR) 成像评估的细胞外体积 (ECV) 与疾病严重程度和患者的结果相关.
- 索引总ECV (iECV) 已被提议作为膜心脏病 (VHD) 的优越预后标志物.
研究的目的:
- 为了比较常规ECV和iECV在接受CMR.患者的广泛队列中的预后能力.
- 确定iECV是否比标准ECV提供额外的预后价值.
主要方法:
- 在2012年1月至2023年期间,一个连续的1525名患者队列通过CMR进行了ECV和iECV测量.
- 不良结果被定义为心力衰竭住院和/或全因死亡率的复合结果.
- 进行了多变量分析,调整了临床因素和心声回声数据.
主要成果:
- 在单变量和多变量分析中,ECV和iECV都与不良结果显著相关.
- 卡普兰-梅尔分析表明,ECV/iECV三位体和无事件生存率之间存在显著的关联.
- 虽然ECV与大动脉门速度相关,但iECV没有显示出显著的关联.
结论:
- 传统的ECV和iECV都是有价值的预后标志物,用于预测心力衰竭住院和死亡在全新手的CMR队列中.
- 尽管iECV复杂,但与标准ECV测量相比,iECV没有显示出附加的预后价值.
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