低剂量电离辐射和甲状腺疾病以及暴露工人的功能性改变:系统性审查
Corrado Colaprico1, Francesca Lomartire1, Ivana Raccio1
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Journal of clinical medicine
|January 25, 2025
概括
低剂量电离辐射 (LDIR) 对工人的暴露可能会影响甲状腺功能,观察到FT3和FT4水平的变化. 虽然与甲状腺癌的直接联系是不确定的,但证据表明甲状腺体体积增加和结节的形成.
科学领域:
- 职业健康 职业健康 职业健康
- 放射学科学 放射学科学
- 内分泌学 在内分泌学.
背景情况:
- 技术进步增加了对电离辐射的职业暴露.
- 电离辐射对甲状腺等特定器官的确切影响尚不清楚.
- 了解低剂量电离辐射 (LDIR) 影响对于工人的安全至关重要.
研究的目的:
- 系统地审查职业LDIR暴露与甲状腺功能变化和癌症发展之间的关系.
- 综合目前关于LDIR对暴露工人的甲状腺健康的影响的证据.
主要方法:
- 观察性研究的系统审查.
- 从三个主要的电子数据库 (PubMed,Scopus,Web of Science) 提取和分析数据.
- 遵守PRISMA指导方针和进行PROSPERO注册 (CRD:42023425839).
主要成果:
- 在对166篇文章进行初步选后,包括了15项研究.
- 暴露于LDIR并没有改变甲状腺刺激激素 (TSH) 水平.
- 观察到的变化包括减少的自由三甲状腺素 (fT3) 和可变的自由甲状腺素 (fT4) 水平.
- 有证据表明甲状腺体体积增加和结节的形成,尽管与甲状腺癌的确切联系尚未确定.
结论:
- 低剂量的电离辐射会对甲状腺功能产生负面影响.
- 需要进一步的研究来充分阐明这些影响,并为工人提供保护措施的信息.
- 职业LDIR暴露需要继续对甲状腺健康进行监测和调查.
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