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Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.

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相关实验视频

Updated: Jul 11, 2026

Luminescence Lifetime Imaging of O2 with a Frequency-Domain-Based Camera System

Luminescence Lifetime Imaging of O2 with a Frequency-Domain-Based Camera System

Published on: December 16, 2019

光终身内镜使用纳秒时隔CAPS摄像头与无IRF深度学习方法.

Pooria Iranian¹, Thomas Lapauw¹, Thomas Van den Dries¹

¹Department of Electronics and Informatics (ETRO), Vrije Universiteit Brussel, 1050 Brussels, Belgium.

Sensors (Basel, Switzerland)

|January 25, 2025

概括

这项研究介绍了tauCAM,这是一个用于实时近红外光寿命成像的新设备. 这项技术增强了内镜中的细胞分化,以更少的数据点提供更高的精度.

关键词:

这些都是CAPS,CAPS.卷积神经网络是一种卷积神经网络.通过内镜检查 (endoscopy) 进行内镜检查光成像成像技术的使用.光终身成像成像光终身成像有门的摄像机.

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Last Updated: Jul 11, 2026

Luminescence Lifetime Imaging of O2 with a Frequency-Domain-Based Camera System

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科学领域:

生物医学光学生物医学光学
医疗成像医学成像
内镜检查是指内镜检查.

背景情况:

光成像在临床前和临床环境中至关重要.
影像技术和光标签的进步推动了光终身成像的采用.
在医学诊断中,区分恶性和良性细胞至关重要.

研究的目的:

开发和演示一个内镜光终身成像系统,以改善细胞分化.
在近红外 (NIR) 区域 (700-900 nm) 实现实时光寿命成像.
评估一种基于深度学习的新方法,以最小的时间点进行光终身成像.

主要方法:

使用电流辅助光子采样器开发tauCAM系统.
用各种幽灵的刚性内镜进行演示.
应用无IRF深度学习算法,只需要6个时间点.

主要成果:

内镜终身成像系统成功展示了其能力.
基于深度学习的方法实现了高精度和一致性的光终身成像.
使用6个时间点的系统在终身统一性和精度方面超过了传统方法.

结论:

内镜光终身成像具有提高医疗诊断的巨大潜力.
开发的tauCAM系统和深度学习方法为实时NIR光寿命成像提供了精确有效的方法.
这项技术可以改善恶性和良性细胞的分化,为先进的内镜手术铺平道路.