在乙型肝炎后的监测 表面抗原的损失:需要注意的问题
Shuai-Wen Huang1,2,3,4, Hong Long1, Jia-Quan Huang3
1Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
Pathogens (Basel, Switzerland)
|January 25, 2025
概括
治疗慢性乙型肝炎 (CHB) 是很困难的. 虽然乙型肝炎表面抗原 (HBsAg) 损失是关键目标,但由于持续的病毒风险,终身监测至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 由于持续的病毒DNA,慢性乙型肝炎 (CHB) 的治愈仍然难以捉摸.
- 乙型肝炎表面抗原 (HBsAg) 损失是目前治疗目标,以改善患者的治疗结果.
- 病毒在HBsAg损失后持续存在的风险包括复发和肝细胞癌.
研究的目的:
- 审查HBsAg损失在CHB管理中的重要性.
- 为了强调持续监测的必要性,尽管HBsAg损失.
- 讨论CHB治疗和监测策略的不断变化的格局.
主要方法:
- 关于CHB治疗结果的最近研究的文献综述.
- 对HBsAg损失后病毒持久性和风险的数据分析.
- 对CHB患者目前和拟议的监测策略的评估.
主要成果:
- 失去HBsAg可以改善肝功能和预后,但不能保证病毒的根除.
- 持续的乙型肝炎病毒 (HBV) DNA 后HBsAg损失与显著的长期风险有关.
- 现有的监测策略需要根据新的结果数据进行改进.
结论:
- 达到HBsAg损失是一个关键的里程碑,但并不能完全治愈CHB.
- 持续的患者随访和监测对于管理HBsAg损失后的风险至关重要.
- 需要进行进一步的长期研究,以优化CHB患者的监测协议.
相关概念视频
Investigation of Disease Outbreaks
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...


