银N-异环碳素 (NHC) 复合物作为抗微生物和/或抗癌剂
Jessica Ceramella1, Alessia Catalano2, Annaluisa Mariconda3
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende, Italy.
Pharmaceuticals (Basel, Switzerland)
|January 25, 2025
概括
银的N-异环碳 (NHC) 金属复合物表现出强大的抗菌和抗癌活性. 本综述强调了最近关于这些有前途的化合物的研究,这些化合物用于双重微生物感染和癌症向.
科学领域:
- 药用化学 医学化学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 微生物感染和癌症之间的联系是很好的,需要双重准策略.
- 金属复合物,特别是N-异环碳素 (NHC) 复合物,在药物化学中是有效的.
- 银 (Ag(I)) -NHC复合物对于联合治疗应用特别有前途.
研究的目的:
- 审查最近在银 (Ag(I)) -NHC复合物的进展.
- 讨论它们的抗菌和抗癌特性和作用机制.
- 提供有关该领域未来研究方向的见解.
主要方法:
- 在科学数据库中进行文献搜索 (PubMed/MEDLINE,Scopus,Google Scholar).
- 专注于过去五年内发表的研究.
- 报告的抗菌和抗癌活性和拟议的机制的分析.
主要成果:
- 许多Ag(I) -NHC复合体表现出显著的抗菌和抗癌作用.
- 一些Ag(I) -NHC复合物在有效性方面优于参考药物.
- 行动机制正在被阐明,显示了双重向的潜力.
结论:
- Ag(I) -NHC复合物代表了对抗微生物感染和癌症的一类非常有前途的化合物.
- 进一步研究它们的机制和应用是有必要的.
- 这些复合体为双重或多重治疗向提供了潜在的战略.
相关概念视频
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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
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02:52Stereoisomerism
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Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
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The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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