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Aspergillus oryzae发酵的Plumula Nelumbinis通过AKT/mTOR和Jun途径对抗亚托皮炎

Fengfeng Chen¹, Jing Liu¹, Xinwei Yu¹

¹Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.

Pharmaceuticals (Basel, Switzerland)

|January 25, 2025

概括

发酵Plumula Nelumbinis (FPN) 通过向关键路径,显示出对抗亚托皮炎 (AD) 的抗炎作用. 发酵增强了Plumula Nelumbinis类化合物的活性,为新的AD药物开发提供了潜力.

科学领域:

药理学药理学是指药理学的学科.
自然产品化学化学
皮肤病学皮肤病学

背景情况:

亚托皮炎 (AD) 是一种普遍存在的慢性炎症性皮肤疾病.
来自Plumula Nelumbinis的类化合物具有抗炎性质.
自然化合物的发酵可以增强它们的治疗潜力,但FPN对AD的疗效在很大程度上是未知的.

研究的目的:

研究发酵Plumula Nelumbinis (FPN) 在治疗阿托皮性皮炎 (AD) 中的治疗疗效和潜在机制.
在AD治疗中识别FPN的关键分子标.
为了评估阿斯伯吉勒斯菌发酵对Plumula Nelumbinis的抗炎活性的影响.

主要方法:

网络药理学被用来预测AD的FPN的潜在治疗点.
聚合酶连锁反应 (PCR) 和西部涂抹 (WB) 用于验证体外治疗效果.
斑马鱼模型被用来评估FPN缓解炎症的能力.

主要成果:

网络药理学确定了mTOR和Jun作为AD的关键目标.
在实验室中,FPN有效抑制了AKT/mTOR和AKT/Jun介导的炎症信号通路.
FPN在减轻斑马鱼中SDS诱导的炎症方面表现出有效性,在发酵油阶段观察到增强的活性.

结论:

这项研究阐明了发酵的Plumula Nelumbinis类化合物的潜在抗皮炎机制.
微生物发酵,特别是Aspergillus oryzae,可以增强Plumula Nelumbinis的抗炎活性.
这些发现为开发由FPN衍生的新型AD疗法提供了科学基础.

关键词:

梅花 Nelumbinis 的一个字母.这是一种类化物.亚托邦性皮肤炎的发生.发酵发酵发酵发酵这是一个机制机制.网络药理学网络药理学

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