纳米载体在提供局部抗氧化剂方面的潜在应用
Zulfan Zazuli1, Rika Hartati2, Cornelia Rosasepti Rowa3
1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia.
Pharmaceuticals (Basel, Switzerland)
|January 25, 2025
概括
皮肤疾病中的氧化应激可以通过局部抗氧化剂来管理. 纳米技术增强了通过皮肤屏障的抗氧化剂输送,提高了各种皮肤疾病的治疗效果.
科学领域:
- 皮肤病学和纳米医学
背景情况:
- 由反应性氧物种 (ROS) 不平衡引起的氧化应激会导致皮肤疾病.
- 皮肤的屏障功能使局部抗氧化剂的输送复杂化.
- 外源抗氧化剂对于减轻ROS损伤至关重要.
研究的目的:
- 审查纳米技术用于增强局部抗氧化剂的应用.
- 探索纳米载体系统,以改善抗氧化剂的皮肤透.
- 讨论抗氧化剂在皮肤健康和疾病中的作用.
主要方法:
- 关于纳米技术在局部抗氧化剂递送中的文献综述.
- 对各种纳米载体系统 (纳米乳液,脂质体,SLN,NLC,聚合物纳米粒子) 的分析.
- 检查ROS形成,抗氧化剂治疗和天然抗氧化剂来源.
主要成果:
- 纳米载体系统显著改善了通过皮肤屏障的抗氧化剂透.
- 特定的纳米载体,如脂质体和固体脂质纳米颗粒,对抗氧化剂的递送显示出有前途.
- 自然抗氧化剂可以有效地封装在纳米载体中,以提高效率.
结论:
- 纳米技术为局部抗氧化剂治疗提供了一种可行的策略,以克服皮肤屏障的挑战.
- 先进的纳米载体系统是加速开发有效的局部抗氧化剂治疗的关键.
- 本次审查强调了纳米技术在促进氧化压力相关疾病的皮肤治疗方面的潜力.
相关概念视频
Drug Delivery: Miscellaneous Routes
305
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
305
Drug Delivery: Overview
276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276


