患有自闭症谱系障碍的儿童的氨基酸模式:初步生物化学评估
Simona Ferraro1, Laura Saielli2, Davide Biganzoli1
1Department of Pediatrics, Buzzi Children's Hospital, 20154 Milan, Italy.
Nutrients
|January 25, 2025
概括
儿童自闭症谱系障碍 (ASD) 显示出血氨基酸 (AA) 概况的改变,其中一些模式可能表明神经问题,而另一些则表明营养不平衡. 需要进一步的研究来理解这些代谢差异.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 在自闭症谱系障碍 (ASD) 中对血氨基酸 (AA) 代谢进行了研究,但结果仍然没有确定性.
- 早期诊断出患有自闭症的儿童需要进一步的代谢表征.
研究的目的:
- 在早期诊断出患有自闭症的儿童中,对血AA概况的改变进行表征.
- 为了比较ASD儿童和神经类型对照之间的AA概况.
- 根据AA个人资料,根据ASD人群中识别潜在的子组.
主要方法:
- 用离子交换染色学分析了有1242名患有自闭症儿童和488名对照儿童的血AA概况.
- 主要组件和集群分析被用来探索关联,并确定ASD队列中的子组.
主要成果:
- 与对照组相比,患有自闭症儿童的谷氨胺水平较低 (p < 0.001).
- 在患有自闭症的儿童中,观察到六种基本的,两种条件基本的和四种非基本的AA水平的增加.
- 集群分析确定了两个子组:NEU (神经) 含高 taurine,阿斯巴甜酸,谷氨酸和鸟酸;和NUT (营养) 含高分支链AAs.
结论:
- 患有自闭症儿童的异质AA模式可以作为生物化学特征.
- 这些模式可能表明一些患有ASD的个体的神经功能受损.
- 在其他个体中,改变的AA档案可能表明营养失调.
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