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适度高蛋白饮食对超重或肥胖者端粒长度的有益影响

Blanca De la Fuente¹, Fermín I Milagro^1,2,3, Marta Cuervo^1,3

¹Department of Nutrition, Food Sciences and Physiology, Center for Nutrition and Research, University of Navarra, 31008 Pamplona, Spain.

|January 25, 2025

概括

适度高蛋白 (MHP) 饮食可以在减肥期间保护端粒长度 (TL),特别是在女性身上. 与低脂肪饮食相比,这种饮食方法可以通过保护端粒来支持更健康的衰老.

科学领域:

细胞生物学细胞生物学
衰老研究研究衰老研究
营养科学营养科学

背景情况:

端粒长度 (TL) 是细胞衰老的生物标志物,与与年龄相关的疾病有关.
生活方式干预对于缓解端粒缩短和预防与年龄相关的疾病至关重要.

研究的目的:

研究两种减肥饮食 - - 中度高蛋白 (MHP) 饮食和低脂肪 (LF) 饮食 - - 对端粒长度的影响.
评估在接受饮食干预的超重或肥胖个体的TL变化.

主要方法:

该研究涉及来自OBEKIT试验的164名参与者 (18-65岁),他们被分配到MHP或LF饮食中4个月.
端粒长度在基线和4个月后使用单色复合量化聚合酶连锁反应 (MMqPCR) 测量.
人类测量,生化和饮食摄入数据被收集和分析.

主要成果:

两个饮食组在人体测量和生化标志物上都显示出显著的改善.
在MHP组显示了TL的增加 (+0.16 ± 0.13),而在LF组显示了TL的减少 (-0.05 ± 0.13) (p = 0.016).
与LF组女性相比,MHP组女性的TL显著增加 (p = 0.001),与较高的蛋白质摄入量相关.

结论:

适度高蛋白饮食可能在减肥期间对端粒长度产生保护作用,对女性尤其有益.
饮食干预应考虑巨量营养素组成,以保持端粒长度并促进更健康的衰老.

关键词:

卡路里限制卡路里限制饮食干预措施饮食干预措施高蛋白质的饮食高蛋白质的饮食.低脂肪饮食低脂肪饮食宏观营养素的分布分布端粒是什么意思端粒是什么意思

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