在ART周期期间,微量营养素抗氧化剂治疗和男性生育能力的改善
Marwa Lahimer1,2, Severine Capelle1, Elodie Lefranc1
1ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, Picardie University Jules Verne, CHU Sud, 80000 Amiens, France.
Nutrients
|January 25, 2025
概括
氧化应激显著损害男性的生育能力和精液质量. 抗氧化剂补充剂在改善不孕男性的精子参数和生殖结果方面表现有前途.
科学领域:
- 生殖生物学 生殖生物学
- 安德罗学与人类学
- 氧化应激研究研究 氧化应激研究
背景情况:
- 氧化应激 (OS) 是男性不孕症的主要原因,影响30-80%的不孕男性.
- 由于多不和脂肪酸和有限的抗氧化防御能力,精子对氧化损伤非常敏感.
- OS导致脂质过氧化,蛋白质氧化,线粒体功能障碍和基因组不稳定性,损害男性生殖功能.
研究的目的:
- 审查抗氧化剂补充对精液参数和体外受精 (IVF) 结果的影响.
- 评估微量营养素抗氧化剂疗法在改善男性生育潜力的作用.
- 综合证据,证明抗氧化剂如何减轻精子中的OS诱导的损伤.
主要方法:
- 对研究抗氧化剂补充剂在男性不孕症中的研究进行系统审查.
- 对精子参数的影响分析:体积,运动性,度,形态.
- 对精子基因组完整性和试管婴儿成功率的影响评估.
主要成果:
- 抗氧化剂疗法显示出在中和自由基和减少细胞损伤方面的潜力.
- 补充L-卡尼丁,辅酶Q10,和等微量营养素可以改善精子质量.
- 有证据表明,通过抗氧化剂干预,精子参数得到改善,并可能有更好的试管婴儿结果.
结论:
- 抗氧化剂补充剂是一种可行的策略,可以抵消男性不孕症中氧化应激.
- 微量营养素抗氧化剂疗法可以增强精子生成,精子生成和精子DNA完整性.
- 均衡的生活方式和足够的抗氧化剂摄入对于改善男性生育能力和生殖健康至关重要.
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