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长效注射剂中的部分AUC:理由,挑战,可变性,有用性和临床相关性

Georgia Tsakiridou1, Maria-Faidra-Galini Angelerou1, Panagiotis Efentakis1

  • 1Pharmathen SA, 31 Spartis Str., 14452 Metamorfosi Attica, Greece.

Pharmaceutics
|January 25, 2025
PubMed
概括

部分AUC (pAUC) 有助于对长效注射剂 (LAI) 的生物等价性测试,但选择切断点是具有挑战性的. 本研究回顾了案例研究,以评估通用LAI开发的pAUC.

关键词:
生物等价性 生物等价性布普伦诺芬 HCL 是一种脱氧化的使用方法兰雷化物是什么莱普罗利德 (leuprolide) 是一种一种长效注射剂 长效注射剂纳尔特雷克森 (Naltrexone) 是一种可以八重胺的使用方法一部分的AUC.药物动力学 药物动力学变化的可变性.

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