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用口服输送的乳酸铁素涂层肠膜颗粒:改善了产品的保质期

Nika Kržišnik¹, Blaž Grilc¹, Robert Roškar¹

¹Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, 1000 Ljubljana, Slovenia.

|January 25, 2025

概括

这项研究使用双涂层技术开发了一种稳定的乳酸铁素 (Lf) 配方,增强其在胃肠道的保护,并在冷藏下将保质期延长到30个月.

科学领域:

食品科学与技术食品科学与技术
生物技术是生物技术.
制药配方制药配方制药配方

背景情况:

铁结合蛋白Lactoferrin (Lf) 具有显著的健康益处,使其成为食品补充剂的宝贵成分.
乳酸易被降解,这对它被纳入稳定有效的补充剂构成了挑战.

研究的目的:

开发一种强大的乳酸铁素 (Lf) 配方,以确保胃肠道内的稳定性.
通过优化配方和储存条件,提高乳酸基产品的保质期.

主要方法:

在中性颗粒芯上采用双层涂层技术,涂上乳酸铁素层和保护性肠道涂层.
利用已建立的工业生产技术进行可扩展的配方开发.

主要成果:

实现了高封装效率为85%的乳酸铁素.
通过溶解试验证明了乳酸对胃消化有有效的保护作用.
延长了乳酸配方的保质期,在冷藏时将近30个月,而在室温下是15个月.

结论:

成功地适应了一种通常用于小分子的涂层技术,以稳定一种基于蛋白质的产品 (乳酸铁素).
开发的配方有效地保护乳酸铁素免受胃肠道的降解.
该配方由于其延长的保质期和稳定性而表现出商业可行性.

关键词:

肠道涂层肠道涂层胃的消化胃的消化乳酸铁素是什么? 乳酸铁素是什么?颗粒颗粒颗粒保质期货架使用寿命稳定的稳定性稳定的稳定性

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