开发使用增材制造技术的新型口服输送系统,以克服未来向药物输送的生物制药挑战
Micol Cirilli1, Julius Krause2, Andrea Gazzaniga1
1Department of Pharmaceutical Sciences, University of Milan, GazzaLaB, via Giuseppe Colombo 71, 20133 Milan, Italy.
Pharmaceutics
|January 25, 2025
概括
一种新的3D打印可扩展药物递送系统成功地准了小肠上部,以改善药物的生物可用性. 这种创新设备在模拟的胃肠道条件下展示了受控扩张,为吸收窗口狭窄的药物提供了有前途的解决方案.
科学领域:
- 制药科学 制药科学
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 针对性的药物输送对于具有狭窄吸收窗口的活性药物成分至关重要,以提高生物可用性.
- 上小肠提供了药物吸收的最佳地点,因为其独特的生理环境.
- 开发先进的输送系统对于克服传统药物管理的局限性至关重要.
研究的目的:
- 设计和原型一种新的3D打印可扩展药物输送系统,用于针对性地向小肠上部输送药物.
- 评估系统的功能,包括器官保留和控制药物释放能力.
- 为了优化弹的几何形状,在输送系统内实现机械强度和灵活性.
主要方法:
- 使用PLA和HPMC材料的3D打印技术 (FDM和SLA) 来制造可扩展设备.
- 嵌入的矩阵和弹具有不同的几何形状,使用纹理分析仪测试机械性能.
- 采用了适合消化器抵抗的链条,以实现紧的配置,旨在在中性pH值下在小肠中溶解.
主要成果:
- 该系统在酸性条件下保持了两个小时的紧状态,证明了稳定性.
- 当pH值变化为6.8时,设备在2.5-5.5分钟内成功膨胀,这取决于弹的大小.
- 可扩展系统展示了恢复其扩展状态的能力,表明持续药物释放的潜力.
结论:
- 这种3D打印的可扩展药物输送系统显示出对小肠上部的向输送有显著的前景.
- 这项技术为具有狭窄吸收窗口的药物管理提供了潜在的替代方案,提高了治疗疗效.
- 需要进一步的体内研究来验证在实际胃肠道环境中的临床潜力和机械稳定性.
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