自乳化药物输送系统 (SEDDS):从液体向固体的过渡-对配方,特性,应用和未来趋势的全面审查
Prateek Uttreja1, Indrajeet Karnik1, Ahmed Adel Ali Youssef2
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.
Pharmaceutics
|January 25, 2025
概括
自乳化药物递送系统 (SEDDS) 提高了药物的溶解性和生物可用性. 从液体形式过渡到固体形式 (S-SEDDS) 提高了稳定性,并实现了先进的应用,如个性化医疗的3D打印.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 水溶性较差的药物会给口服药物带来很大的挑战.
- 自乳化药物递送系统 (SEDDS) 通过提高溶解性和生物可用性提供解决方案.
- 液体SEDDS (L-SEDDS) 面临稳定性和泄漏问题,需要进行改进.
研究的目的:
- 审查SEDDS的进展和应用,重点关注向固体形式 (S-SEDDS) 的过渡.
- 探索SEDDS的制定策略,表征技术和未来前景.
- 突出SEDDS开发中的新兴趋势,如3D打印和混合系统.
主要方法:
- 对SEDDS分类 (液体与固体) 的现有研究进行系统分析.
- 详细检查制备方法:喷雾干燥,热挤出,载体吸附.
- 探索特征化技术:滴滴大小,溶解,固态评估.
主要成果:
- 固体SEDDS (S-SEDDS) 克服了L-SEDDS的局限性,提供了更好的稳定性,可扩展性和患者合规性.
- 新兴创新包括3D打印的SEDDS,生物药物输送,向系统和超和SEDDS (Su-SEDDS).
- 计算建模加速了SEDDS的配方优化.
结论:
- SEDDS已经彻底改变了药物输送,改善了生物可用性,并使以患者为中心的疗法成为可能.
- 尽管存在可扩展性和助剂毒性等挑战,但SEDDS对于下一代药物开发至关重要.
- 个性化医疗的适应性和潜力将SEDDS作为现代制药的基石.
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