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基于全身生理学上的GalNAc结合siRNAs的药动力学建模

Emilie Langeskov Salim1,2, Kim Kristensen2, Erik Sjögren1

  • 1Department of Pharmaceutical Bioscience, Translational Drug Discovery and Development, Uppsala University, SE-75124 Uppsala, Sweden.

Pharmaceutics
|January 25, 2025
PubMed
概括

N-乙-银胺小干扰RNAs (GalNAc-siRNA) 证明了持久的蛋白质淘汰. 一个新的全身生理学基础的药理动力学-药理动力学 (WB-PBPK-PD) 模型有助于理解GalNAc-siRNA药物处置和PK-PD关系.

关键词:
在ASGPR的基础上,ASGPR是ASGPR.这就是GalNAcc.在PK-Sim中使用PK-Sim.这是一个风险,风险.基于生理学的药物动力学建模.siRNA 是一个RNA.

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