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双机制胃养片与封装的根提取物
Jelena Mudrić1, Ljiljana Đekić2, Nemanja Krgović1
1Institute for Medicinal Plants Research "Dr. Josif Pančić", 11000 Belgrade, Serbia.
Pharmaceutics
|January 25, 2025
概括
用根提取物制成的胃养片被开发出来,以提高皮克洛的生物可用性. 粘膜粘合剂浮动系统增强了局部胃作用,并确保了肠道释放,克服了短半衰期的挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 自然产品化学 自然产品化学
背景情况:
- 甘 (Gentiana lutea) 根提取物含有甘皮克,一种具有全身作用但生物可用性差和半衰期短的生物活性化合物.
- 开发胃系统的目的是通过改善吸收和延长作用来增强 gentiopicroside 的治疗疗效.
研究的目的:
- 为了制定和描述粘膜粘合剂漂浮性胃药片,封装根提取物.
- 为了优化配方,提高 gentiopicroside 的生物可用性和局部胃作用.
主要方法:
- 含有根提取物的固体脂质微粒使用冷解双乳液制备.
- 通过使用二碳酸和微粒直接压缩生产了片.
- 设计质量 (QbD) 原则用于评估关键的配方和过程参数.
主要成果:
- 树脂含量和高切割均质化时间被确定为影响配方特性的关键因素.
- 优化的配方实现了高Gentiopicroside封装效率 (95.13%),良好的稳定性和流动性.
- 开发的片子显示出足够的粘合性,浮动滞后时间 (275秒) 和双相基因皮克化物释放,保持稳定18个月.
结论:
- 成功开发了双机制的胃养药片,用于根提取物输送.
- 该配方抵抗胃酶,确保药物在小肠中释放,即使胃快速排空.
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