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模拟皮肤中空洞的微针介导药物递送,考虑药物结合

Tanmoy Bhuimali¹, Sarifuddin², Diganta Bhusan Das³

¹Department of Mathematics, Visva-Bharati University, Santiniketan 731235, WB, India.

|January 25, 2025

概括

这项研究模拟了空心微针 (HMN) 药物输送,发现皮肤粘性弹性和HMN设计影响药物吸收. 尖端直径和注射速度是有效的微针治疗的关键参数.

科学领域:

药理学药理学是指药理学的学科.
生物医学工程生物医学工程
计算生物学计算生物学

背景情况:

基于微针 (MN) 的药物输送为口服和皮下治疗方法提供了替代方案.
开发了一种基于空心微针 (HMN) 的 in silico 模型,用于药物输送.
该模型结合了间歇流动,药物结合动力学,以及皮肤,血液和组织区间的吸收.

研究的目的:

用一个in silico模型量化理解基于HMN的药物输送.
研究皮肤特性和HMN设计对药物运输和吸收的影响.
探索药物结合和间歇性流动对维拉帕米尔药理动学的影响.

主要方法:

开发了一个用于HMN药物输送的in silico模型.
利用结合的标记器和单元和沉浸边界方法来解决治理方程.
在粘性弹性皮肤中模拟维拉帕米尔运输,具有特定的,可和的结合.

主要成果:

粘弹性皮肤阻碍了维拉帕米尔的运输,降低了血液和组织中的度.
皮肤度的最佳MN长度不仅仅取决于MN长度.
减少尖端直径会增加血液和结缔组织的维拉帕米尔;增加注射速度会增加自由组织的维拉帕米尔.

结论:

新奇之处在于在具有非线性结合的2D粘性弹性皮肤中建模维拉帕米尔代谢.
HMN尖端直径和注射速度可以调节MN治疗的疗效.
对于成功的微针介导药物输送,HMN设计参数至关重要.

关键词:

视角比率的比例是什么药物结合药物结合药物结合有空洞的微针.注射速度的注射速度.间歇性流体间歇性流体粘弹性皮肤粘弹性皮肤

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