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库尔库载脂纳米颗粒:一种有前途的抗菌策略,用于对抗内感染中的Enterococcus faecalis

Sónia Ferreira¹, Liliana Grenho^2,3, Maria Helena Fernandes^2,3

¹University Institute of Health Sciences (IUCS), Cooperative CESPU, CRL, 4585-116 Gandra, Portugal.

|January 25, 2025

概括

含有黄素的固体脂质纳米颗粒对Enterococcus faecalis产生强烈的抗菌作用. 这些纳米粒子是稳定的,对人类细胞是安全的,对牙科治疗有前景.

科学领域:

纳米技术纳米技术
微生物学微生物学
生物材料是一种生物材料.

背景情况:

黄素 (CUR) 是一种天然的多,具有抗微生物和抗炎性质.
改善黄素的可溶性和输送对于其治疗应用至关重要.
Enterococcus faecalis 是一个重要的病原体在内牙感染.

研究的目的:

为了评估加载黄素的固体脂质纳米颗粒 (CUR-SLNs) 对Enterococcus faecalis的疗效.
评估CUR-SLNs的物理化学特性,稳定性和释放特征.
为了确定CUR-SLNs与人类牙纤维细胞的细胞相容性.

主要方法:

使用 cetyl palmitate 和 Tween 80 通过热超声波来制备 CUR-SLN.
评估了物理化学性质 (尺寸,表面潜力,稳定性,释放特征).
抗微生物活性测试了对静态和浮游生物的E. faecalis;细胞毒性被评估在人类纤维细胞.

主要成果:

CUR-SLNs的尺寸为~200 nm,表面电位为-25 mV,并且在100小时内持续释放CUR.
纳米粒子在4°C和25°C下至少两个月表现出稳定性.
CUR-SLNs显示了对E. faecalis的剂量和时间依赖的抗菌活性,以及与人类纤维细胞的良好细胞相容性.

结论:

载有CUR的固体脂质纳米颗粒对E. faecalis.具有显著的抗菌疗效.
开发的纳米粒子具有有利的物理化学特性,稳定性和细胞相容性.
CUR-SLNs显示出作为内牙治疗中有效的辅助疗法的潜力.

关键词:

菌 (Enterococcus faecalis) 是一种菌.它具有抗菌活性,具有抗菌活性.库尔库明是一种黄素.细胞相容性细胞相容性牙周内科治疗牙周内科治疗脂质纳米颗粒的使用方法

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