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从纳米纤维素/纳米孔复合材料中模拟扩散和药物释放的有限元素方法

Paulo Zúñiga1, Marcelo Aravena1, Silvia Ponce2

  • 1Department of Mathematical and Physical Sciences, Catholic University of Temuco, Temuco 4813302, Chile.

Pharmaceutics
|January 25, 2025
PubMed
概括

这项研究开发了一种有限元素方法,用于模拟纳米纤维素/纳米孔复合材料的甲基蓝释放. 该方法准确地预测释放率,显示材料成分对药物输送控制的影响.

关键词:
复合材料 复合材料 是一种复合材料.药物输送是药物输送的过程.有限元素方法的有限元素方法.纳米纤维素的纳米纤维素.纳米多孔的.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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