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溶解微针阵列的最佳几何是什么? 一个文学评论

Maira Visscher1, Henderik W Frijlink1, Wouter L J Hinrichs1

  • 1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.

Pharmaceutics
|January 25, 2025
PubMed
概括

溶解微针阵列 (DMNA) 提供无痛的药物输送. 在施用过程中,最佳的DMNA几何结构对于有效的皮肤透和机械完整性至关重要.

关键词:
设计 设计 设计 设计溶解微针的方法药物输送系统是药物输送系统.几何学几何学几何学在皮肤内,皮肤内皮肤.机械强度 机械强度 机械强度优化的优化优化优化.皮肤插入插入皮肤插入.穿透皮肤 穿透皮肤通过皮肤通过皮肤.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...