病毒转录和瘤免疫微环境基于HPV相关的头甲状腺癌的转录形状分析 确定与预后相关的亚型
Anastasiia Nikitina1, Daria Kiriy1, Andrey Tyshevich1
1BostonGene Corp., Waltham, MA 02453, USA.
Viruses
|January 25, 2025
概括
人类乳头瘤病毒 (HPV) 阳性头癌显示出与预后相关的独特瘤微环境 (TME). 像E2/E5这样的HPV转录模式与更好的生存率和免疫丰富的TME相关.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的头角状细胞癌 (HNSCC) 与HPV阴性HNSCC相比,具有独特的生物特征.
- 瘤微环境 (TME) 在癌症的进展和患者的结果中起着关键作用.
研究的目的:
- 使用人工智能驱动的平台在HPV阳性HNSCC中分类不同的瘤微环境 (TME) 亚型.
- 调查HPV转录表达模式,TME亚型和患者预后之间的相关性.
主要方法:
- 基于人工智能的元队列分析,以分析病毒转录,HPV基因组集成和TME特征.
- 基于病毒基因表达的无监督聚类来识别TME亚型和HPV相关亚型.
- 确定亚型与患者生存数据之间的相关性分析.
主要成果:
- 确定了五种新的TME亚型:免疫丰富,高度免疫和B细胞丰富,纤维化,免疫沙漠和免疫丰富的光,所有与预后相关.
- 根据HPV转录表达,确定了四种与HPV相关的亚型 (E2/E5,E6/E7,E1/E4,L1/L2).
- E2/E5型HPV亚型与免疫丰富的TME,缺乏HPV基因组集成,以及改善整体存活率有关.
- E6/E7亚型与纤维化和免疫性沙漠TME相关,免疫细胞特征减少,生存率较差.
结论:
- 在HPV阳性HNSCC中,HPV转录表达模式显著影响瘤微环境 (TME).
- 特定的HPV转录亚型,如E2/E5,与有利的TME和更好的患者预后有关.
- 了解这些HPV-TME相互作用可以为HPV阳性HNSCC的治疗策略提供信息.
更多相关视频
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.6K
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
10.3K
相关概念视频
lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
