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Magdalena Kal^1,2, Michał Brzdęk^1,3, Izabella Karska-Basta^4,5

¹Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.

|January 25, 2025

概括

像Alpha和Delta这样的COVID-19变种对眼睛的微循环有不同的影响. 阿尔法变体与减少的状血管密度和更大的状血管区域有关,而三角形变体在表面和深层毛细管中显示出血管密度下降.

科学领域:

眼科医生眼科眼科
病毒学病毒学
微循环是一种微循环.

背景情况:

感染SARS-CoV-2的临床症状多种多样,严重程度可能与特定的病毒变种有关.
已知COVID-19对眼睛微循环的影响,但SARS-CoV-2血统之间的差异仍未得到调查.

研究的目的:

用光学连贯断层扫描血管学 (OCTA) 来比较感染SARS-CoV-2阿尔法和三角形变体的患者的眼部微循环变化.
评估SARS-CoV-2的阿尔法和三角线系之间是否存在眼部微血管效应的差异.

主要方法:

一项前性研究,将患有Alpha或DeltaSARS-CoV-2变体的患者与对照组进行比较.
OCTA的测量包括表面毛细血管 (SCP),深毛细血管 (DCP) 和胆毛细血管 (CCP) 的血管密度 (VD).
在SCP (FAZs) 和DCP (FAZd) 中手动评估状血管区域.

主要成果:

在检查期间,在任何变体组中都没有报告眼部症状.
在所有象限中,Delta组在SCP和DCP中表现出明显较低的VD (p < 0.001-0.039).
阿尔法组表现出减少的骨中枢中心视觉损伤 (p = 0.005) 和显著更宽的FAZ和FAZd (p = 0.002).

结论:

在SARS-CoV-2Alpha和Delta变体之间,眼部微循环的改变有所不同.
阿尔法变体感染与状冠状动脉疾病的减少和FAZs的扩大有关.
德尔塔变种感染与多个地区的SCP和DCPVD减少有关,需要对变种特定的COVID-19患者进行随访.

关键词:

阿尔法变种的阿尔法变种.在 COVID-19 疫情中,达尔塔变种的特种变种足骨非血管区 (FOVAL AVASCULAR ZONE) 是指足骨非血管区 (FOVAL AVASCULAR ZONE) 的一个区域.光学连贯性断层扫描血管图谱船舶密度是指船舶的密度.

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