肝炎E病毒对男性生殖系统的影响:对当前证据的审查
Ahmed A Kotb1, Mohamed A El-Mokhtar2, Ibrahim M Sayed3
1Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt.
Viruses
|January 25, 2025
概括
肝炎E病毒 (HEV) 可以感染男性生殖系统,可能导致不孕. 这次审查评估了HEV.
科学领域:
- 病毒学 病毒学
- 生殖医学 生殖医学
- 公共卫生 公共卫生
背景情况:
- 肝炎E病毒 (HEV) 导致急性肝炎和肝外表现.
- 对于HEV对男性生殖系统的影响研究不足,数据是相互矛盾的.
- 在慢性感染期间,HEV颗粒被排泄到精液中,这引发了传播的担忧.
研究的目的:
- 批判性地审查和综合目前关于HEV对男性生殖系统影响的研究.
- 研究不同HEV基因型与男性生殖功能障碍之间的关联.
- 评估HEV的性传播潜力.
主要方法:
- 对调查HEV和男性生殖健康的研究进行文献综述.
- 对人类和动物研究结果的分析.
- 在精液中对HEV分泌的评估及其传染性.
主要成果:
- 在动物模型中,HEV感染可能会导致丸损伤,血液丸屏障破坏和精子异常.
- 一项人类研究将HEV基因型4与男性不孕症联系起来.
- 在慢性感染期间,HEV在精液中分泌,但没有证实性传播.
结论:
- 高血压病毒感染可能导致男性生殖功能障碍,特别是在特定的基因型.
- 需要进一步的研究来证实HEV与男性不孕症之间的联系.
- 目前的证据不支持HEV的性传播.
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