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人类致病性冠状病毒和动物冠状病毒研究的动物模型

Fenglian Xiao^1,2, Jincheng Hu¹, Minsheng Xu¹

¹School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.

|January 25, 2025

概括

开发冠状病毒的先进动物模型对于对抗人类和动物疾病至关重要. 本综述详细介绍了创建易感模型的进展情况,并建议对未来对冠状病毒感染的研究进行改进.

科学领域:

兽医医学兽医医学兽医医学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

冠状病毒对人类和动物健康构成重大威胁,需要强大的研究工具.
用于研究冠状病毒感染的各种动物模型,包括非人类灵长类动物,,仓鼠和老鼠.
最近的进展侧重于通过诸如病毒受体诱导和遗传修饰等方法提高动物模型易感性.

研究的目的:

为新冠肺炎研究提供当前动物模型的全面概述.
突出最近在开发对人类和动物冠状病毒敏感的动物模型方面的进展.
建议策略,以提高动物模型在未来研究中的实用性.

主要方法:

对冠状病毒感染的动物模型现有文献的审查.
分析用于增强动物模型易感性的技术 (例如病毒传递,基因编辑).
检查来自牲畜和物模型的数据,以获得临床见解.

主要成果:

对多种冠状病毒的感染模型的成功建立使得研究进步.
转基因小鼠和增强的传递方法增加了对感染的易感性.
牲畜和物模型提供了有价值的临床数据,但未得到充分利用.

结论:

动物模型的持续开发和改进对于了解和控制冠状病毒流行病至关重要.
需要进一步的研究,以充分利用牲畜和物模型的潜力.
调整现有模型并探索新的方法将提高它们在打击冠状病毒疾病中的价值.

关键词:

动物动物动物动物动物动物动物模型动物模型临床表现的临床表现.冠状病毒冠状病毒的新冠病毒.人类人类人类人类人类人类人类感染的感染感染.

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