在关节整形术后的老年患者中,不同血栓预防疗程的比较
Qi Zhang1, Xuan Sun2, Jingbo Pan1
1Department of Osteoarthritis, Yantai City Yantai Shan Hospital, Yantai, Shandong, China.
British journal of hospital medicine (London, England : 2005)
|January 25, 2025
概括
间歇性气压 (IPC) 的早期使用,然后在48小时后使用低分子量肝素 (LMWH),在预防关节置换后的深静脉血栓症 (DVT) 方面与早期LMWH一样有效,出血较少.
科学领域:
- 整形外科手术 整形外科手术
- 血管医学 血管医学
- 老年医学 老年医学
背景情况:
- 深静脉血栓 (DVT) 是关节整形术后的一种常见的术后并发症,特别是在老年患者中.
- 预防DVT对于降低该患者群体的发病率和死亡率至关重要.
研究的目的:
- 评估早期间歇性肺压缩 (IPC) 的有效性,然后在48小时后用低分子量肝素 (LMWH) 预防下肢DVT,在接受关节整形的老年患者中.
- 为了将这种顺序方法与早期LMWH启动 (手术后12小时) 进行对比,关于DVT发生率,凝血参数和术后并发症.
主要方法:
- 对100名接受单边大腿骨头置换的老年患者进行了回顾性研究.
- 对照组 (n=55):手术后12小时开始的LMWH.
- 观察组 (n=45):手术后48小时开始的IPC跟随LMWH.
主要成果:
- 两组之间DVT发生率没有显著差异 (p > 0.05).
- 两组都显示出显著的凝血参数变化,干预后没有组间差异 (p > 0.05).
- 观察组的术后失血,周围伤口血瘤和输血率明显较低 (p < 0.05).
结论:
- 顺序IPC和延迟LMWH (48小时) 与早期LMWH (12小时) 在老年关节整形患者的DVT预防方面相当.
- 这种顺序方法显著降低了术后出血风险,并显示出高安全性.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
602
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
602
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
146
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
146
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
462
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
462


