可修改风险因素对内皮细胞甲基组和心血管疾病发展的影响
1School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, SE5 9NU London, UK.
Frontiers in bioscience (Landmark edition)
|January 25, 2025
概括
环境风险因素会改变内皮DNA甲基化,可能导致内皮功能障碍和心血管疾病 (CVD). 本综述探讨了糖尿病和吸烟等因素如何影响内皮.
科学领域:
- 心血管科学 心血管科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 心血管疾病 (CVD),包括动脉样硬化,是导致死亡的主要原因.
- 动脉样硬化涉及动脉加厚,并与血管细胞中的DNA甲基化变化有关.
- 内皮功能障碍 (ED) 是一种早期动脉样硬化标志物,可能是由内皮DNA甲基化变化驱动的.
研究的目的:
- 审查将环境风险因素与内皮DNA甲基化变化联系在一起的证据.
- 探索这些表观遗传变化如何导致内皮功能障碍和心血管疾病.
- 考虑风险因素影响DNA甲基化调节器 (DNMT和TET) 的机制.
主要方法:
- 对环境风险因素和内皮表观遗传学研究的文献综述.
- 对影响DNA甲基转移酶 (DNMTs) 和十一转移酶 (TETs) 的分子机制的分析.
- 讨论氧气,α-甲酸和铁在TET蛋白活性中的作用.
主要成果:
- 环境因素 (糖尿病,吸烟,高血压等) 改变了内皮甲基组.
- 这些修改改变了基因转录和内皮细胞功能.
- TET蛋白活性对低氧,代谢状态和氧化还原有敏感,影响甲基组.
结论:
- 可修改的风险因素显著影响内皮DNA甲基化模式.
- 受风险因素影响的内皮甲基组的变化与ED和CVD有关.
- 了解这些表观遗传机制为预防心血管疾病提供了潜在的治疗点.
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