安卓代谢类固醇会在血管内皮细胞中引起醇失衡
Halszka Ponamarczuk1, Maria Światkowska1, Marcin Popielarski1
1Department of Cytobiology and Proteomics, Medical University of Lodz, 92-215 Lodz, Poland.
Frontiers in bioscience (Landmark edition)
|January 25, 2025
概括
长期使用安卓代谢类固醇 (AAS) 会损害血管内皮细胞的功能,影响细胞的增殖和迁移. 这些影响与二硫化物不平衡和运动员潜在的心血管损伤有关.
科学领域:
- * 生物化学 * 生物化学
- * 细胞生物学 * 细胞生物学
- * 运动医学 运动医学
背景情况:
- * 安卓代谢类固醇 (AAS) 是合成的衍生物,在体育运动中被广泛滥用.
- * AAS滥用与严重的心血管损伤有关,包括血液静止和凝血问题.
- * AASs通过抑制氧化介导的扩张和损害内皮细胞生长而对血管功能产生负面影响.
研究的目的:
- * 为了研究长期使用安卓代谢类固醇 (AAS) 对血管内皮细胞功能的影响.
- * 确定雄激素受体在内皮细胞对AASs敏感性的作用.
- *阐明了AAS诱导的内皮功能障碍背后的分子机制.
主要方法:
- *培养的血管内皮细胞用南德罗隆和博尔登 (AAS) 进行了七天的化.
- *使用的试验包括跨井和移动试验,以评估细胞迁移和增殖.
- * 超内皮电阻 (TEER) 试验用于评估单层完整性.
主要成果:
- * AAS暴露显著减少了内皮细胞的增殖,迁移和单层形成.
- *观察到过氧化素 (PRDX1,PRDX2) 的下调,这表明醇-二硫化物平衡受到破坏.
- * AAS增加了谷氨氧化和改变了蛋白质二硫化异构酶 (PDI) 分泌和醇模式.
结论:
- *长期使用AAS会导致硫化-硫化不平衡,并损害血管内皮细胞功能.
- *这些细胞变化有助于血管内皮功能障碍,可能解释AAS滥用运动员的心血管并发症.
- *这些发现突出了AAS对内皮健康的有害影响,独立于高剂量的雌激素受体表达.
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