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Updated: Jun 13, 2025

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用抗CGRP单克隆抗体进行为期三年的治疗改变了偏头痛的过程:前性多中心I-GRAINE研究
Piero Barbanti1,2, Cinzia Aurilia3, Paola Torelli4
1Headache and Pain Unit, IRCCS San Raffaele Roma, Via Della Pisana 235, 00163, Rome, Italy. piero.barbanti@sanraffaele.it.
Journal of neurology
|January 25, 2025
概括
将抗CGRP mAb治疗延长至三年以后,显著改善了偏头痛的结果. 用这些抗体进行长期治疗导致偏头痛频率和影响持续减少,这表明偏头痛疾病过程的有利修改.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 偏头痛是一种衰弱的神经系统疾病.
- 素基因相关 (CGRP) 单克隆抗体 (mAbs) 有效预防偏头痛.
- 延长CGRP mAb治疗超过三年对偏头痛过程的长期影响尚未完全理解.
研究的目的:
- 评估延长抗CGRP mAb治疗超过三年对偏头痛频率和负担的影响.
- 在连续三个12个月的治疗周期后,在治疗中断期间分析偏头痛的过程.
主要方法:
- 一项多中心,前性,现实研究,涉及212名患有高频发作性偏头痛或慢性偏头痛的患者.
- 患者完成了三个12个月的皮下抗CGRP mAbs.的循环.
- 偏头痛频率,每月偏头痛日 (MMD),每月头痛日 (MHD),止痛剂摄入量 (MAI),疼痛强度 (NRS) 和头痛影响 (HIT-6) 在每个治疗周期 (D1,D2,D3) 后的第一个月被评估.
主要成果:
- 50%以上的应答率逐渐从D1的25%增加到D3的77.8% (p < 0.001).
- 与D2相比,D3显示出响应率 (77.8%对53.8%),MMD (-2.1天),MHD (-2.9天),MAI (-2.6),NRS (-0.7) 和HIT-6 (-7.2) (p < 0.001) 的显著改善.
- 慢性偏头痛和药物过度使用的复发率在D3与D1和D2相比,在D3显著较低.
结论:
- 经过三年的抗CGRP mAb治疗,反应率逐渐增加.
- 长期治疗导致偏头痛负担大幅减少,复发率降低.
- 延长的抗CGRP mAb疗法可能有利地改变偏头痛的长期进程.
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