人类胚胎植入:子宫内膜受体和微生物群之间的复杂相互作用
Shiyang Peng1, Amu Qingsan Meri1, Min Zhou2
1Chengdu Fifth People's Hospital, (School of Medical and Life Sciences/Affiliated Fifth People's Hospital, Chengdu University of Traditional Chinese Medicine), Chengdu, China.
Journal of reproductive immunology
|January 25, 2025
概括
阴道的微生物组
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 遗传学 是一个遗传学.
背景情况:
- 生殖道的微生物群对健康和疾病至关重要.
- 了解子宫内膜和阴道微生物群的差异对于生殖结果至关重要.
- 微生物组在冷胚胎移植 (FET) 成功中的作用尚未完全理解.
研究的目的:
- 研究接受FET的女性阴道和子宫内膜微生物群之间的差异.
- 确定生殖道微生物组组成与FET后怀孕结果之间的关联.
- 确定与成功胚胎植入相关的特定微生物模式.
主要方法:
- 招募了120名接受体外受精 (IVF) /细胞内精子注射 (ICSI) 和胚胎冷的妇女.
- 在第一次冷解胚胎移植过程中收集了阴道和子宫微生物组样本.
- 使用下一代测序进行了16S rRNA基因测序 (V3-V4区域).
主要成果:
- 与孕妇相比,非孕妇的阴道细菌丰富性和多样性更高,乳酸菌和加德内拉菌水平较低,与孕妇相比更高.
- 怀孕和非怀孕组之间没有观察到子宫微生物群多样性的显著差异.
- 非怀孕组在子宫腔中表现出显著较低的乳酸菌和伪菌水平.
结论:
- 女性生殖道微生物组组成与冷解胚胎移植中的怀孕结果相关.
- 在生殖系统中以乳酸菌为主导的微生物组与更高的临床和持续怀孕率有关.
- 准或调节微生物组可能会提高FET成功率.
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