Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Teratogenicity01:07

Teratogenicity

2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

273
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
273
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

316
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
316
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

361
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
361
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

52.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
52.4K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

124
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
124

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Untreated epilepsy and pregnancy.

Seizure·2026
Same author

Lamotrigine as an antiseizure medication in pregnancy.

Seizure·2026
Same author

Teratogenicity of zonisamide and other little-used antiseizure medications.

Seizure·2024
Same author

Pregnancy, antiseizure medications and unexplained intrauterine foetal death.

Epilepsy & behavior : E&B·2024
Same author

The teratogenesis risk associated with antiseizure medication duotherapy in women with epilepsy.

Epilepsy research·2024
Same author

W. J. Adie and his "pyknolepsy," a century ago.

Journal of the history of the neurosciences·2023

相关实验视频

Updated: May 30, 2025

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.2K

拉莫特里金是一种催产素吗?

Frank Je Vajda1, Simon R L Vajda2, Mervyn J Eadie3

  • 1Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, 3050, Australia.

Seizure
|January 25, 2025
PubMed
概括
此摘要是机器生成的。

这项研究研究了拉莫特里金 (LTG) 单一治疗的情况,发现胎儿形率略高,尽管在统计学上并不显著 (4.49%) 与未经治疗的怀孕 (3.27%) 相比,胎儿形率略高. 需要进一步的研究来确认LTG是否是一种弱原体.

关键词:
抗发作药物 抗发作药物胎儿发育不良的情况拉莫特里基因 (Lamotrigine) 是一种单疗法是一种单疗法.怀孕 怀孕 怀孕 怀孕产性 产性 产性

更多相关视频

Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry
08:59

Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry

Published on: July 17, 2017

12.9K
Generation of Transgenic Rats using a Lentiviral Vector Approach
09:07

Generation of Transgenic Rats using a Lentiviral Vector Approach

Published on: May 17, 2020

8.6K

相关实验视频

Last Updated: May 30, 2025

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.2K
Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry
08:59

Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry

Published on: July 17, 2017

12.9K
Generation of Transgenic Rats using a Lentiviral Vector Approach
09:07

Generation of Transgenic Rats using a Lentiviral Vector Approach

Published on: May 17, 2020

8.6K

科学领域:

  • 神经学 神经学
  • 药理学 药理学是指药理学的学科.
  • 甲状腺学 甲状腺学

背景情况:

  • 抗发作药物 (ASM) 对于在怀孕期间治疗至关重要.
  • 拉莫特里金 (LTG) 是一种常用的ASM,但其致病性潜力需要仔细评估.
  • 了解ASM单一治疗相关的风险对于患有的女性生殖健康至关重要.

研究的目的:

  • 确定拉莫特里金 (LTG) 是否作为单一抗发作药物 (ASM) 时,作为原体起作用.
  • 为了比较暴露于LTG单一治疗的怀孕中的胎儿形率与未暴露的怀孕.

主要方法:

  • 分析了从490名接受LTG单疗的妇女的怀孕数据.
  • 与患有的女性214次怀孕的比较,这些妇女在怀孕早期没有接触到ASM.
  • 统计分析包括后勤回归来评估剂量依赖性和风险比率.

主要成果:

  • 在暴露于LTG的怀孕中观察到4.49%的胎儿形 (FM) 发生率,而未经治疗的怀孕中为3.27% (风险比率=1.37).
  • 没有发现统计学上有意义的证据表明LTG单疗是一种原体 (P <0.05).
  • 后勤回归没有表明LTG和形风险之间的剂量依赖关系,尽管受影响的身体区域不同.

结论:

  • 研究结果并没有明确排除拉莫特里金作为潜在的弱原体.
  • 观察到的形率增加,虽然在统计学上并不显著,但需要谨慎解释.
  • 使用这些LTG单疗数据作为其他ASM的基准,可能会导致关于其安全性的潜在误导性结论.