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在人口密集的社区中,特定于家庭垃圾的环境空气显示出更大的可吸入抗微生物耐药性风险

Zhipeng Zheng¹, Wenhui Ji¹, Xiao Wang²

¹Shanghai Engineering Research Center of Biotransformation of Organic Solid Waste, School of Ecological and Environmental Science, East China Normal University, Shanghai 200241, PR China; Chongqing Key Laboratory of Precision Optics, Chongqing Institute of East China Normal University, Chongqing 401120, PR China.

Waste management (New York, N.Y.)

|January 25, 2025

概括

家庭垃圾将抗生素耐药性基因释放到空气中的颗粒中,造成健康风险. 废物中的病原细菌可以感染居民,在城市地区由于更长时间的吸入暴露,风险更高.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

家庭垃圾是抗生素耐药性的重要来源.
抗生素耐药性基因 (ARG) 可以释放到空气中的颗粒物 (PM10).
空气传播的ARG与致病细菌和居民健康风险的关联尚未得到充分理解.

研究的目的:

调查空气中的PM10中ARG的存在和来源.
为了识别与空气传播的ARGs相关的致病细菌.
评估空气传播抗生素耐药性对城市居民造成的健康风险.

主要方法:

空气中的PM10和环境样本的高通量元基因组测序.
基于培养的抗生素耐药性的验证.
使用iCAMP进行细菌群体聚集的分析.
估计ARG起源和水平基因转移 (HGT) 潜力.

主要成果:

温暖潮湿的季节显示,与寒冷干燥的季节相比,PM10相关的抗生素耐药性显著更高.
大约30%的空气中的ARG来自家庭垃圾.
废物特定细菌 (例如,Acinetobacter,Pseudomonas) 是ARG的主要空气宿主.
抗生素耐药的病原体如Pseudomonas aeruginosa和Acinetobacter baumannii显示出高HGT潜力和感染风险.

结论:

家庭垃圾对空气中的抗生素耐药性有很大影响.
从废物中传播到空气中的细菌构成感染风险,特别是在长时间的吸入暴露时.
由于人口密度和暴露时间,城市社区面临来自空气传播抗生素耐药性的更高健康负担.

关键词:

在空气中传播的PM(10)抗生素耐药性基因是抗生素耐药性的基因.社区的风险暴露是什么家庭垃圾是家庭垃圾.吸入风险评估吸入风险评估基于元基因组学的方法.

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